DISCOVERY OF GENE REGULATION PATTERN IN LUNG CANCER BY GENE EXPRESSION PROFILING USING HUMAN TISSUES


SV40 miR-S1 and Cellular miR-1266 Sequester Each Other from Their Targets, Enhancing Telomerase Activity and Viral Replication

Virus-encoded microRNAs (miRNAs) target viral and host mRNAs to repress protein production from viral and host genes, and regulate viral persistence, cell transformation, and evasion of the immune system.The present study demonstrated that simian virus 40 (SV40)-encoded miRNA miR-S1 targets a cellular miRNA miR-1266 to derepress their respective ta

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Bioengineering the Oxygen-Deprived Tumor Microenvironment Within a Three-Dimensional Platform for Studying Tumor-Immune Interactions

Oxygen deprivation within tumors is one of the most prevalent causes of resilient cancer cell survival and increased immune evasion in breast cancer (BCa).Current in vitro models do not adequately mimic physiological oxygen levels relevant to breast tissue and its tumor-immune interactions.In this study, we propose an approach to engineer a three-d

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Initial or salvage treatment with apatinib shows promise against radioiodine-refractory differentiated thyroid carcinoma

Objective: Sorafenib and lenvatinib have been recommended as standard tyro sine kinase inhibitors (TKIs) for progressive radioiodine-refractory differentiated thyroid carcinoma (RR-DTC).However, their efficacy remains limited with unresolved drug resistance.Therefore, we conceived this open-label study based on real-world evidence to investigate th

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